The fifth meeting of the series History and philosophy of science: historical traditions and epistemological perspectives is focused on historical epistemology, an integrative approach to the history and philosophy of science deeply rooted in the European tradition of epistemology. Hans-Jörg Rheinberger, one of the leading exponents of this approach will present his own perspective, focused on the epistemology of scientific practice and on the dynamical role of experimental systems in the establishment, persistence and change of “epistemic objects” (My view on historical epistemology). Laurent Loison will deal with the criticalities of the relationship between past and present in the light of historical epistemology (More on historical epistemology: critical presentism), while Daniel Pietro Omodeo will highlight the political implications of its endeavor (Genesis, validity and the objectives of science: The triad of political epistemology).